Ishibashi Research Laboratory

Nobuyuki Ishibashi, MD

Dr. Ishibashi joined the faculty of Boston University Chobanian & Avedisian School of Medicine in March 2025 as a Professor of Anatomy & Neurobiology. Prior to this transition, he spent 19 years at Children’s National Hospital in Washington, DC, where he served as a Principal Investigator at the Center for Neuroscience Research and Director of the Cardiac Surgery Research Laboratory, and held the Foglia-Hills Chair in Pediatric Cardiac Research.

Dr. Ishibashi earned his medical degree from Gunma University School of Medicine in Japan in 1998. He completed clinical training in Surgery, Cardiovascular Surgery, and Pediatric Cardiac Surgery at the Heart Institute of Japan, Tokyo Women’s Medical University, obtaining certifications from both the Japanese Board of Surgery and the Japanese Board of Cardiovascular Surgery. He further advanced his research training through a postdoctoral fellowship at the Center for Neuroscience Research at Children’s National Hospital.

Contact Info: nishibas@bu.edu

Selected Publications

  1. Outer radial glia promotes white matter regeneration after neonatal brain injury .
    Jinnou H, Rosko L, Yamashita S, Henmi S, Prasad J, Lam VK, Agaronyan A, Tsang-Wei T, Imamura Y, Kuboyama K, Sawamoto K, Hashimoto-Torii K, Ishibashi N, Gallo V.
    Cell Rep Med. 2025;6(3):101986.
  2. Mesenchymal Stromal Cells Mitigate Prolonged Cardiopulmonary Bypass-Induced Neuroinflammation .
    Kobayashi K, Maeda T, Saric N, Sarkislali K, Furuta A, McCann CD, Hanley PJ, Zurakowski D, Ishibashi N.
    Interdiscip Cardiovasc Thorac Surg. 2025;40(11):ivaf267.
  3. The role of primary cilia in congenital heart defect-associated neurological impairments .
    Saric N, Ishibashi N.
    Front Genet. 2024;15:1460228.
  4. Establishing optimal control cohorts for phase 1 trials: retrospective analysis of clinical and biological outcomes in neonates and infants undergoing two-ventricle repair .
    Kobayashi K, Kobayashi K, Liu C, Ryan J, Zurakowski D, Ishibashi N.
    Pediatr Cardiol. 2024.
  5. Mesenchymal Stromal Cell Delivery Via Cardiopulmonary Bypass Provides Neuroprotection in a Juvenile Porcine Model .
    Sarkislali K, Kobayashi K, Sarić N, Maeda T, Henmi S, Somaa FA, Bansal A, Tu SC, Leonetti C, Hsu CH, Li J, Vyas P, Kawasawa YI, Tu TW, Wang PC, Hanley PJ, Hashimoto-Torii K, Frank JA, Jonas RA, Ishibashi N.
    JACC Basic Transl Sci. 2023;8(12):1521-1535.
  6. Trajectories of neurodevelopment and opportunities for intervention across the lifespan in congenital heart disease .
    Sanz JH, Cox S, Donofrio MT, Ishibashi N, McQuillen P, Peyvandi S, Schlatterer S.
    Child Neuropsychol. 2023;29(7):1128-1154.
  7. Defining the optimal historical control group for a phase 1 trial of mesenchymal stromal cell delivery through cardiopulmonary bypass in neonates and infants .
    Kobayashi K, Higgins T, Liu C, Ayodeji M, Wernovsky G, Jonas RA, Ishibashi N.
    Cardiol Young. 2023;33(9):1523-1528.
  8. Dose Effect of Mesenchymal Stromal Cell Delivery Through Cardiopulmonary Bypass .
    Kobayashi K, Maeda T, Ayodeji M, Tu SC, Chen A, Rajtboriraks M, Hsu CH, Tu TW, Wang PC, Hanley PJ, Jonas RA, Ishibashi N.
    Ann Thorac Surg. 2023;116(6):1337-1345.
  9. Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity .
    Sarić N, Hashimoto-Torii K, Jevtović-Todorović V, Ishibashi N.
    Trends Neurosci. 2022;45(6):446-458.
  10. The Current Status of Neuroprotection in Congenital Heart Disease .
    Kobayashi K, Liu C, Jonas RA, Ishibashi N.
    Children (Basel). 2021;8(12):1116.
  11. Impact of Cardiopulmonary Bypass on Neurogenesis and Cortical Maturation .
    Dhari Z, Leonetti C, Lin S, Prince A, Howick J, Zurakowski D, Wang PC, Jonas RA, Ishibashi N.
    Ann Neurol. 2021;90(6):913-926.
  12. Influence of administration of mesenchymal stromal cell on pediatric oxygenator performance and inflammatory response .
    Maeda T, Briggs CM, Datar A, Brantner CA, Hanley PJ, Jonas RA, Ishibashi N.
    JTCVS Open. 2021;5:99-107.
  13. Impact of Mesenchymal Stromal Cell Delivery Through Cardiopulmonary Bypass on Postnatal Neurogenesis .
    Maeda T, Sarkislali K, Leonetti C, Kapani N, Dhari Z, Al Haj I, Ulrey R, Hanley PJ, Jonas RA, Ishibashi N.
    Ann Thorac Surg. 2020;109(4):1274-1281.
  14. Treatment With Tetrahydrobiopterin Improves White Matter Maturation in a Mouse Model for Prenatal Hypoxia in Congenital Heart Disease .
    Romanowicz J, Leonetti C, Dhari Z, Korotcova L, Ramachandra SD, Saric N, Morton PD, Bansal S, Cheema A, Gallo V, Jonas RA, Ishibashi N.
    J Am Heart Assoc. 2019;8(15):e012711.
  15. Cortical Dysmaturation in Congenital Heart Disease .
    Leonetti C, Back SA, Gallo V, Ishibashi N.
    Trends Neurosci. 2019;42(3):192-204.
  16. Microstructural Alterations and Oligodendrocyte Dysmaturation in White Matter After Cardiopulmonary Bypass in a Juvenile Porcine Model .
    Stinnett GR, Lin S, Korotcov AV, Korotcova L, Morton PD, Ramachandra SD, Pham A, Kumar S, Agematsu K, Zurakowski D, Wang PC, Jonas RA, Ishibashi N.
    J Am Heart Assoc. 2017;6(8):e005997.
  17. Neurodevelopmental Abnormalities and Congenital Heart Disease: Insights Into Altered Brain Maturation .
    Morton PD, Ishibashi N, Jonas RA.
    Circ Res. 2017;120(6):960-977.
  18. Abnormal neurogenesis and cortical growth in congenital heart disease .
    Morton PD, Korotcova L, Lewis BK, Bhuvanendran S, Ramachandra SD, Zurakowski D, Zhang J, Mori S, Frank JA, Jonas RA, Gallo V, Ishibashi N.
    Sci Transl Med. 2017;9(374):eaah7029.
  19. Hypoxia diminishes the protective function of white-matter astrocytes in the developing brain .
    Agematsu K, Korotcova L, Morton PD, Gallo V, Jonas RA, Ishibashi N.
    J Thorac Cardiovasc Surg. 2016;151(1):265-72.
  20. Prolonged White Matter Inflammation After Cardiopulmonary Bypass and Circulatory Arrest in a Juvenile Porcine Model .
    Korotcova L, Kumar S, Agematsu K, Morton PD, Jonas RA, Ishibashi N.
    Ann Thorac Surg. 2015;100(3):1030-7.
  21. Congenital cardiac anomalies and white matter injury .
    Morton PD, Ishibashi N, Jonas RA, Gallo V.
    Trends Neurosci. 2015;38(6):353-63.
  22. Effects of preoperative hypoxia on white matter injury associated with cardiopulmonary bypass in a rodent hypoxic and brain slice model .
    Agematsu K, Korotcova L, Scafidi J, Gallo V, Jonas RA, Ishibashi N.
    Pediatr Res. 2014;75(5):618-25.
  23. Rodent brain slice model for the study of white matter injury .
    Murata A, Agematsu K, Korotcova L, Gallo V, Jonas RA, Ishibashi N.
    J Thorac Cardiovasc Surg. 2013;146(6):1526-1533.
  24. White matter protection in congenital heart surgery .
    Ishibashi N, Scafidi J, Murata A, Korotcova L, Zurakowski D, Gallo V, Jonas RA.
    Circulation. 2012;125(7):859-71.