Dr. Nemanja Saric is a Senior Research Scientist whose work bridges developmental neuroscience and neurodevelopmental disorders. He completed his BSc in Molecular Genetics and PhD in Developmental Neuroscience at King’s College London, and subsequently conducted postdoctoral training at the Center for Neuroscience Research at Children’s National Medical Center in Washington D.C. His research focuses on understanding how early-life molecular and physiological perturbations reshape cortical circuit maturation and constrain plasticity across the lifespan.
He integrates CRISPR-based gene editing, transgenic mouse models, AAV-based circuit engineering and projection-specific viral strategies, single-cell transcriptomics, and multiphoton imaging during awake behavior to connect gene regulation with dendritic spine dynamics and circuit-level function. By combining precise genetic manipulation with in vivo structural imaging and behavioral analysis, his work bridges molecular programming, synaptic architecture, and adaptive learning.
His overarching goal is to define the developmental mechanisms through which early molecular disturbances become embedded into circuit structure and to identify targeted strategies capable of restoring adaptive cortical plasticity in neurodevelopmental disorders. Through this framework, he aims to translate mechanistic insight into principled therapeutic approaches for CHD-associated cognitive impairment and autism spectrum conditions.
Contact Info: nsaric@bu.edu
